Journal article
Delayed development of specific thyroid hormone-regulated events in transthyretin null mice
JA Monk, NA Sims, KM Dziegielewska, RE Weiss, RG Ramsay, SJ Richardson
American Journal of Physiology Endocrinology and Metabolism | AMER PHYSIOLOGICAL SOC | Published : 2013
Abstract
Thyroid hormones (THs) are vital for normal postnatal development. Extracellular TH distributor proteins create an intravascular reservoir of THs. Transthyretin (TTR) is a TH distributor protein in the circulatory system and is the only TH distributor protein synthesized in the central nervous system. We investigated the phenotype of TTR null mice during development. Total and free 3′,5′,3,5-tetraiodo-L-thyronine (T4) and free 3′,3,5- triiodo-L-thyronine (T3) in plasma were significantly reduced in 14- day-old (P14) TTR null mice. TTR null mice also displayed a delayed suckling-to-weaning transition, decreased muscle mass, delayed growth, and retarded longitudinal bone growth. In addition, i..
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Funding Acknowledgements
J. A. Monk was supported by a University of Melbourne Postgraduate Research Scholarship. S. J. Richardson was supported by an Australia Research Council Research Fellowship. K. M. Dziegielewska was supported by the National Institutes of Health (USA) and NHMRC (Australia). This work was supported by an Australian Research Council grant to S. J. Richardson and an NHMRC (Australia) Program grant to N. A. Sims. R. G. Ramsay and N. A. Sims are NHMRC Senior Research Fellows.